Biblioteca Humberto Rosselli Quijano
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Ejemplares (1)
| Código de barras | Signatura | Tipo de medio | Ubicación | Sección | Estado |
|---|---|---|---|---|---|
| 102134 | Journal of the American Academy of Child & Adolescent Psychiatry | Publicaciones seriadas | Biblioteca Instituto Colombiano del Sistema Nervioso | Col. General | Disponible |
Artículos
Añadir el resultado a su cestaAdaptive intervention for school-age, minimally verbal children with autism spectrum disorder in the community: primary aim results / Connie Kasari en Journal of the American Academy of Child & Adolescent Psychiatry, Año 2025 - Vol. 64 - No. 6 (Junio)
Título : Adaptive intervention for school-age, minimally verbal children with autism spectrum disorder in the community: primary aim results Tipo de documento: texto impreso Autores: Connie Kasari, Autor ; Stephanie Shire, Autor ; Wendy Shih, Autor Fecha de publicación: 2025 Artículo en la página: pp. 674-685 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: Intervención mínimamente verbal, Diseño SMART, JASP-EMT, DTT Resumen: The goal of this study is to construct a 16-week, 2-stage, adaptive intervention consisting of DTT (Discrete Trials Training, largely considered usual care for children with autism), JASP-EMT (a blended, naturalistic, developmental behavioral intervention involving JASPER [Joint Attention, Symbolic Play, Engagement and Regulation] and EMT [Enhanced Milieu Teaching]), and parent training (P) for improving spontaneous communicative utterances in school-aged, minimally verbal autistic children. Link: ./index.php?lvl=notice_display&id=31619
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 674-685[artículo] Adaptive intervention for school-age, minimally verbal children with autism spectrum disorder in the community: primary aim results [texto impreso] / Connie Kasari, Autor ; Stephanie Shire, Autor ; Wendy Shih, Autor . - 2025 . - pp. 674-685.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 674-685
Etiquetas: Intervención mínimamente verbal, Diseño SMART, JASP-EMT, DTT Resumen: The goal of this study is to construct a 16-week, 2-stage, adaptive intervention consisting of DTT (Discrete Trials Training, largely considered usual care for children with autism), JASP-EMT (a blended, naturalistic, developmental behavioral intervention involving JASPER [Joint Attention, Symbolic Play, Engagement and Regulation] and EMT [Enhanced Milieu Teaching]), and parent training (P) for improving spontaneous communicative utterances in school-aged, minimally verbal autistic children. Link: ./index.php?lvl=notice_display&id=31619
Título : The impact of using standardized autism screening on referral to specialist evaluation for young children on the autism spectrum: a cluster-randomized controlled trial Tipo de documento: texto impreso Autores: Giacomo Vivanti, Autor ; Yasemin Algur, Autor ; Victoria Ryan, Autor Fecha de publicación: 2025 Artículo en la página: pp. 686-698 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: Autismo, Ensayo aleatorio, Detección de autismo, Diagnóstico, M-CHAT Resumen: We tested whether the implementation of standardized, high-fidelity screening for autism during routine well-child check-ups results in the following: increasing the number of children with suspected autism referred to diagnostic evaluation; lowering the age at which they are referred; and facilitating autism diagnosis for children across a more diverse range of demographic backgrounds and clinical presentations, including those with subtle manifestations. Link: ./index.php?lvl=notice_display&id=31620
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 686-698[artículo] The impact of using standardized autism screening on referral to specialist evaluation for young children on the autism spectrum: a cluster-randomized controlled trial [texto impreso] / Giacomo Vivanti, Autor ; Yasemin Algur, Autor ; Victoria Ryan, Autor . - 2025 . - pp. 686-698.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 686-698
Etiquetas: Autismo, Ensayo aleatorio, Detección de autismo, Diagnóstico, M-CHAT Resumen: We tested whether the implementation of standardized, high-fidelity screening for autism during routine well-child check-ups results in the following: increasing the number of children with suspected autism referred to diagnostic evaluation; lowering the age at which they are referred; and facilitating autism diagnosis for children across a more diverse range of demographic backgrounds and clinical presentations, including those with subtle manifestations. Link: ./index.php?lvl=notice_display&id=31620
Título : Implementing a uniform outcome measurement approach for early interventions of autism spectrum disorders Tipo de documento: texto impreso Autores: Deanna Swain, Autor ; Yi Li, Autor ; Hallie R. Brown, Autor Fecha de publicación: 2025 Artículo en la página: pp. 699-709 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: Trastornos del espectro autista, Intervención temprana, Medidas de resultados Resumen: Naturalistic developmental behavioral interventions for children with autism spectrum disorder show evidence for effectiveness for specific social communication targets such as joint attention or engagement. However, combining evidence from different studies and comparing intervention effects across those studies have not been feasible due to lack of a standardized outcome measure of broader social communication skills that can be applied uniformly across trials. Link: ./index.php?lvl=notice_display&id=31621
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 699-709[artículo] Implementing a uniform outcome measurement approach for early interventions of autism spectrum disorders [texto impreso] / Deanna Swain, Autor ; Yi Li, Autor ; Hallie R. Brown, Autor . - 2025 . - pp. 699-709.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 699-709
Etiquetas: Trastornos del espectro autista, Intervención temprana, Medidas de resultados Resumen: Naturalistic developmental behavioral interventions for children with autism spectrum disorder show evidence for effectiveness for specific social communication targets such as joint attention or engagement. However, combining evidence from different studies and comparing intervention effects across those studies have not been feasible due to lack of a standardized outcome measure of broader social communication skills that can be applied uniformly across trials. Link: ./index.php?lvl=notice_display&id=31621
Título : Early-onset trajectories of emotional dysregulation in autistic children Tipo de documento: texto impreso Autores: Teresa Bennett, Autor ; Marc Jambon, Autor ; Anat Zaidman-Zait, Autor Fecha de publicación: 2025 Artículo en la página: pp. 710-723 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: Autismo, Estudio de cohorte, Desregulación emocional, Depresión parental, Trayectorias Resumen: Emotional dysregulation (ED) is a common and debilitating problem for autistic children and their families. However, little is known about early-onset patterns of dysregulation, associated risk factors, and child and family outcomes. This study aimed to characterize trajectories of ED in an inception cohort of autistic preschoolers. Link: ./index.php?lvl=notice_display&id=31622
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 710-723[artículo] Early-onset trajectories of emotional dysregulation in autistic children [texto impreso] / Teresa Bennett, Autor ; Marc Jambon, Autor ; Anat Zaidman-Zait, Autor . - 2025 . - pp. 710-723.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 710-723
Etiquetas: Autismo, Estudio de cohorte, Desregulación emocional, Depresión parental, Trayectorias Resumen: Emotional dysregulation (ED) is a common and debilitating problem for autistic children and their families. However, little is known about early-onset patterns of dysregulation, associated risk factors, and child and family outcomes. This study aimed to characterize trajectories of ED in an inception cohort of autistic preschoolers. Link: ./index.php?lvl=notice_display&id=31622
Título : The impact of early life adversity on peripubertal accelerated epigenetic aging and psychopathology Tipo de documento: texto impreso Autores: Christina M. Hogan, Autor ; Sarah M. Merrill, Autor ; Evelyn Hernandez Valencia, Autor Fecha de publicación: 2025 Artículo en la página: pp. 724-733 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: Reloj epigenético bucal pediátrico, Amenaza, Deprivación, Internalización, Externalización Resumen: To examine longitudinal associations between early life threat and deprivation on epigenetic age acceleration at ages 9 and 15 years, and to examine associations of age acceleration on later internalizing and externalizing symptoms. Link: ./index.php?lvl=notice_display&id=31623
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 724-733[artículo] The impact of early life adversity on peripubertal accelerated epigenetic aging and psychopathology [texto impreso] / Christina M. Hogan, Autor ; Sarah M. Merrill, Autor ; Evelyn Hernandez Valencia, Autor . - 2025 . - pp. 724-733.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp. 724-733
Etiquetas: Reloj epigenético bucal pediátrico, Amenaza, Deprivación, Internalización, Externalización Resumen: To examine longitudinal associations between early life threat and deprivation on epigenetic age acceleration at ages 9 and 15 years, and to examine associations of age acceleration on later internalizing and externalizing symptoms. Link: ./index.php?lvl=notice_display&id=31623
Título : Racial implicit associations in child psychiatry Tipo de documento: texto impreso Autores: Katie A. Malison, Autor ; Victor J. Avila Quintero, Autor ; Cheryl S. Al Mateen, Autor Fecha de publicación: 2025 Artículo en la página: pp.734-744 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: Discriminación racial, Sesgo implícito racial, Pediátrico, Disparidades en salud, Equidad Resumen: Racial disparities in diagnosis and treatment are prevalent in child psychiatry, including disparate diagnosis rates of internalizing and externalizing disorders in Black and White children. However, limited research has investigated mechanisms that contribute to these disparities. This study examined child racial implicit associations in psychiatric clinicians and medical students to address this gap. Link: ./index.php?lvl=notice_display&id=31624
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp.734-744[artículo] Racial implicit associations in child psychiatry [texto impreso] / Katie A. Malison, Autor ; Victor J. Avila Quintero, Autor ; Cheryl S. Al Mateen, Autor . - 2025 . - pp.734-744.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp.734-744
Etiquetas: Discriminación racial, Sesgo implícito racial, Pediátrico, Disparidades en salud, Equidad Resumen: Racial disparities in diagnosis and treatment are prevalent in child psychiatry, including disparate diagnosis rates of internalizing and externalizing disorders in Black and White children. However, limited research has investigated mechanisms that contribute to these disparities. This study examined child racial implicit associations in psychiatric clinicians and medical students to address this gap. Link: ./index.php?lvl=notice_display&id=31624
Título : A General Factor of Psychopathology Predicts Treatment and Long-Term Outcomes in Children and Adolescents With Obsessive-Compulsive Disorder Tipo de documento: texto impreso Fecha de publicación: 2025 Artículo en la página: pp 799-809 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: salud mental de los adolescentes, investigación intercultural, estructura factorial, invarianza de la medición, Cuestionario de Fortalezas y Dificultades (SDQ) Resumen: Objective The self-report Strengths and Difficulties Questionnaire (SDQ) is widely used globally; hence, the validity of the intergroup comparisons is essential. This study examined the structure of the self-report SDQ in a large multinational adolescent sample, tested its measurement invariance across genders and countries, and compared youth mental health in 12 European and Asian countries.Method This study is part of the Eurasian Child Mental Health Study (EACMHS), a cross-cultural research study of child and adolescent well-being and mental health in 12 Asian and European countries. The sample (N = 26,306) came from a cross-sectional school-based survey of adolescents. Confirmatory factor analysis was used to assess a common measurement model for the self-report SDQ and the measurement invariance of the model across gender and country.Results Fit indices in the total sample, in each gender, and in each of the 12 countries separately supported the use of the first-order 3-factor model (without the reverse-coded items) as a common measurement model for the self-report SDQ. Measurement invariance analyses provided good support for configural, metric, and scalar invariance across gender; however, metric invariance across countries was not supported. There were significant gender main effects for all SDQ subscales except for hyperactivity/inattention. Culture had significant main effects and moderated the magnitude of gender differences in all subscales.Conclusion The present findings support the use of the correlated 3-factor model comprising the positive dimension of prosocial behavior and 2 broad groupings of internalizing and externalizing problems, without the reverse-coded problem items, as a common measurement model for the self-report SDQ internationally.Plain language summary Using a sample of 26,306 adolescents from 12 European and Asian countries, this study examined how well the Strengths and Difficulties Questionnaire (SDQ), a commonly used measure to assess child and adolescent mental health, can be used to compare child and adolescent mental health between different countries. In addition, the authors also measured adolescent mental health symptoms across the 12 countries. The study findings suggested that in all countries, girls scored higher than boys on prosocial behaviors and internalizing problems such as symptoms of depression and anxiety. However, the extent to which genders differed on these features varied across cultures. Link: ./index.php?lvl=notice_display&id=31646
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp 799-809[artículo] A General Factor of Psychopathology Predicts Treatment and Long-Term Outcomes in Children and Adolescents With Obsessive-Compulsive Disorder [texto impreso] . - 2025 . - pp 799-809.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp 799-809
Etiquetas: salud mental de los adolescentes, investigación intercultural, estructura factorial, invarianza de la medición, Cuestionario de Fortalezas y Dificultades (SDQ) Resumen: Objective The self-report Strengths and Difficulties Questionnaire (SDQ) is widely used globally; hence, the validity of the intergroup comparisons is essential. This study examined the structure of the self-report SDQ in a large multinational adolescent sample, tested its measurement invariance across genders and countries, and compared youth mental health in 12 European and Asian countries.Method This study is part of the Eurasian Child Mental Health Study (EACMHS), a cross-cultural research study of child and adolescent well-being and mental health in 12 Asian and European countries. The sample (N = 26,306) came from a cross-sectional school-based survey of adolescents. Confirmatory factor analysis was used to assess a common measurement model for the self-report SDQ and the measurement invariance of the model across gender and country.Results Fit indices in the total sample, in each gender, and in each of the 12 countries separately supported the use of the first-order 3-factor model (without the reverse-coded items) as a common measurement model for the self-report SDQ. Measurement invariance analyses provided good support for configural, metric, and scalar invariance across gender; however, metric invariance across countries was not supported. There were significant gender main effects for all SDQ subscales except for hyperactivity/inattention. Culture had significant main effects and moderated the magnitude of gender differences in all subscales.Conclusion The present findings support the use of the correlated 3-factor model comprising the positive dimension of prosocial behavior and 2 broad groupings of internalizing and externalizing problems, without the reverse-coded problem items, as a common measurement model for the self-report SDQ internationally.Plain language summary Using a sample of 26,306 adolescents from 12 European and Asian countries, this study examined how well the Strengths and Difficulties Questionnaire (SDQ), a commonly used measure to assess child and adolescent mental health, can be used to compare child and adolescent mental health between different countries. In addition, the authors also measured adolescent mental health symptoms across the 12 countries. The study findings suggested that in all countries, girls scored higher than boys on prosocial behaviors and internalizing problems such as symptoms of depression and anxiety. However, the extent to which genders differed on these features varied across cultures. Link: ./index.php?lvl=notice_display&id=31646
Título : Do Ethnic Identity, Familial, and Community Contexts Impact the Association Between Adverse Childhood Experiences and Psychopathology Among Latinx Adolescents? Tipo de documento: texto impreso Fecha de publicación: 2025 Artículo en la página: pp 822-834 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: psicopatología infantil, jóvenes latinos, experiencias adversas en la infancia, trauma, Estudio sobre el desarrollo cognitivo del cerebro adolescente Resumen: Objective Few studies have explored the interplay of how individual identity, parental, familial, and contextual factors impact associations between Latinx adolescent adversities and psychopathology. This study aimed to examine whether these factors mediate the relationship between adversities and psychopathology in Latinx youth.Method Latinx youth (n = 2,411) data from the Adolescent Brain Cognitive Development (ABCD) Study were used to examine path models with adverse childhood experiences (ACEs) as the predictor and either youth- or caregiver-rated internalizing/externalizing scores over 4 timepoints as the outcome (ages 9-13 years). Models examined 3 potential mediators: (1) ethnic identity, (2) familial context (comprising parental monitoring, family conflict, and caregiver acceptance), and (3) community cohesion. Models were conducted separately for internalizing and externalizing symptoms.Results Greater adversity was associated with greater youth- and caregiver-rated internalizing/externalizing psychopathology over time. Greater adversity was associated with lower family functioning and lower ethnic identity, and greater family functioning was associated with lower psychopathology. Family functioning mediated associations between adversity and psychopathology over time (youth-reported internalizing: 95% CI = 0.012-0.019; youth-reported externalizing: 95% CI = 0.020-0.028). In contrast, there was not strong evidence for ethnic identity and community cohesion mediating associations between adversities and psychopathology over time.Conclusion Unlike previous studies, ethnic identity did not influence the relationship between ACEs and psychopathology over time. Additional research is needed to identify whether possible tensions rise as Latinx youth acculturate into US culture and achieve optimal levels of ethnic identity formation. Providers need to assess specific Latinx parental and familial contexts that may interfere with youth identity formation.Plain language summary Using data regarding 2,411 Latinx youth who participated in the Adolescent Brain Cognitive Development (ABCD) study, the authors found that greater adolescent adversities like witnessing a crime, discrimination, unsafe neighborhoods, financial adversity, and acculturative stress related to lower family functioning and greater youth- and caregiver-rated internalizing/externalizing psychopathology over time. Family functioning mediated the link between adversities and psychopathology. Efforts should be devoted to supporting and strengthening family functioning to enhance Latinx child well-being and prevent psychopathology. Link: ./index.php?lvl=notice_display&id=31647
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp 822-834[artículo] Do Ethnic Identity, Familial, and Community Contexts Impact the Association Between Adverse Childhood Experiences and Psychopathology Among Latinx Adolescents? [texto impreso] . - 2025 . - pp 822-834.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp 822-834
Etiquetas: psicopatología infantil, jóvenes latinos, experiencias adversas en la infancia, trauma, Estudio sobre el desarrollo cognitivo del cerebro adolescente Resumen: Objective Few studies have explored the interplay of how individual identity, parental, familial, and contextual factors impact associations between Latinx adolescent adversities and psychopathology. This study aimed to examine whether these factors mediate the relationship between adversities and psychopathology in Latinx youth.Method Latinx youth (n = 2,411) data from the Adolescent Brain Cognitive Development (ABCD) Study were used to examine path models with adverse childhood experiences (ACEs) as the predictor and either youth- or caregiver-rated internalizing/externalizing scores over 4 timepoints as the outcome (ages 9-13 years). Models examined 3 potential mediators: (1) ethnic identity, (2) familial context (comprising parental monitoring, family conflict, and caregiver acceptance), and (3) community cohesion. Models were conducted separately for internalizing and externalizing symptoms.Results Greater adversity was associated with greater youth- and caregiver-rated internalizing/externalizing psychopathology over time. Greater adversity was associated with lower family functioning and lower ethnic identity, and greater family functioning was associated with lower psychopathology. Family functioning mediated associations between adversity and psychopathology over time (youth-reported internalizing: 95% CI = 0.012-0.019; youth-reported externalizing: 95% CI = 0.020-0.028). In contrast, there was not strong evidence for ethnic identity and community cohesion mediating associations between adversities and psychopathology over time.Conclusion Unlike previous studies, ethnic identity did not influence the relationship between ACEs and psychopathology over time. Additional research is needed to identify whether possible tensions rise as Latinx youth acculturate into US culture and achieve optimal levels of ethnic identity formation. Providers need to assess specific Latinx parental and familial contexts that may interfere with youth identity formation.Plain language summary Using data regarding 2,411 Latinx youth who participated in the Adolescent Brain Cognitive Development (ABCD) study, the authors found that greater adolescent adversities like witnessing a crime, discrimination, unsafe neighborhoods, financial adversity, and acculturative stress related to lower family functioning and greater youth- and caregiver-rated internalizing/externalizing psychopathology over time. Family functioning mediated the link between adversities and psychopathology. Efforts should be devoted to supporting and strengthening family functioning to enhance Latinx child well-being and prevent psychopathology. Link: ./index.php?lvl=notice_display&id=31647
Título : Developmental Differences in a Hippocampal–Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure Tipo de documento: texto impreso Fecha de publicación: 2025 Artículo en la página: pp 835-850 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: aprendizaje de la seguridad, trauma, resonancia magnética funcional, amígdala, hipocampo Resumen: Objective Nearly 65% of youth experience trauma, and up to one-third of youth with trauma exposure face profound mental health sequelae. There remains a need to elucidate factors that contribute to psychopathology following trauma exposure, and to optimize interventions for youth who do not benefit sufficiently from existing treatments. Here, we probe safety signal learning (SSL), which is a mechanism of fear reduction that leverages learned safety to inhibit fear in the presence of threat-associated stimuli and has been shown to attenuate fear via a hippocampal–cingulate––specifically, a dorsal anterior cingulate cortex (dACC)––pathway.Method The present study used behavioral and task-based functional magnetic resonance imaging data to examine age-related associations between interpersonal trauma exposure and the behavioral and neural correlates (ie, activation and functional connectivity) of SSL in a group of 102 youth (aged 9-19 years; 46 female, 56 male) with (n = 52) and without (n = 50) interpersonal trauma exposure. Primary analyses examined anterior hippocampal activation and anterior hippocampus–dACC functional connectivity. Exploratory analyses examined centromedial amygdala (CMA) and laterobasal amygdala (LBA) activation and anterior hippocampal, CMA, and LBA functional connectivity with additional anterior cingulate subregions (ie, subgenual anterior cingulate cortex [sgACC] and rostral anterior cingulate cortex [rosACC]).Results Both youth with and without interpersonal trauma exposure successfully learned conditioned safety, which was determined by using self-report of contingency awareness. Youth with interpersonal trauma exposure (relative to youth in the comparison group) exhibited age-specific patterns of lower hippocampal activation (F2,96 = 3.75, pFDR = .049, ηp2 = 0.072), and, in exploratory analyses, showed heightened centromedial amygdala activation (F1,96 = 5.37, pFDR = .046, ηp2 = 0.053) and an age-related decrease in hippocampal–sgACC functional connectivity during SSL (F1,94 = 10.68, pFDR = .015, ηp2 = 0.102). We also show that hippocampal–sgACC functional connectivity mediated the association between interpersonal trauma exposure and post-traumatic stress disorder symptoms in an age-specific manner in the overall sample.Conclusion Together, these findings suggest that although age- and trauma-specific differences in the neural correlates of SSL may relate to the development of psychopathology, youth with interpersonal trauma exposure demonstrate successful learning of conditioned safety over time.Plain language summary Childhood trauma is a major risk factor for the development of psychiatric conditions such as posttraumatic stress disorder (PTSD). Using cross-sectional analysis, this study examined age-related differences in safety signal learning and its neural correlates among youth (N=102) ages 9 to 19 with and without exposure to interpersonal trauma. The authors found that youth exposed to trauma successfully learned about cues signaling safety; however, they showed age-related differences in hippocampal-frontoamygdala circuitry during safety signal learning that might relate to risk for PTSD at specific developmental stages. These findings can inform efforts to promote safety learning and optimize developmentally focused interventions for youth with PTSD.Diversity & Inclusion Statement We worked to ensure that the study questionnaires were prepared in an inclusive way. We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. While citing references scientifically relevant for this work, we also actively worked to promote sex and gender balance in our reference list. While citing references scientifically relevant for this work, we also actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our reference list. We actively worked to promote sex and gender balance in our author group. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. One or more of the authors of this paper received support from a program designed to increase minority representation in science.
Link: ./index.php?lvl=notice_display&id=31648
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp 835-850[artículo] Developmental Differences in a Hippocampal–Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure [texto impreso] . - 2025 . - pp 835-850.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2025 - Vol. 64 - No. 6 (Junio) . - pp 835-850
Etiquetas: aprendizaje de la seguridad, trauma, resonancia magnética funcional, amígdala, hipocampo Resumen: Objective Nearly 65% of youth experience trauma, and up to one-third of youth with trauma exposure face profound mental health sequelae. There remains a need to elucidate factors that contribute to psychopathology following trauma exposure, and to optimize interventions for youth who do not benefit sufficiently from existing treatments. Here, we probe safety signal learning (SSL), which is a mechanism of fear reduction that leverages learned safety to inhibit fear in the presence of threat-associated stimuli and has been shown to attenuate fear via a hippocampal–cingulate––specifically, a dorsal anterior cingulate cortex (dACC)––pathway.Method The present study used behavioral and task-based functional magnetic resonance imaging data to examine age-related associations between interpersonal trauma exposure and the behavioral and neural correlates (ie, activation and functional connectivity) of SSL in a group of 102 youth (aged 9-19 years; 46 female, 56 male) with (n = 52) and without (n = 50) interpersonal trauma exposure. Primary analyses examined anterior hippocampal activation and anterior hippocampus–dACC functional connectivity. Exploratory analyses examined centromedial amygdala (CMA) and laterobasal amygdala (LBA) activation and anterior hippocampal, CMA, and LBA functional connectivity with additional anterior cingulate subregions (ie, subgenual anterior cingulate cortex [sgACC] and rostral anterior cingulate cortex [rosACC]).Results Both youth with and without interpersonal trauma exposure successfully learned conditioned safety, which was determined by using self-report of contingency awareness. Youth with interpersonal trauma exposure (relative to youth in the comparison group) exhibited age-specific patterns of lower hippocampal activation (F2,96 = 3.75, pFDR = .049, ηp2 = 0.072), and, in exploratory analyses, showed heightened centromedial amygdala activation (F1,96 = 5.37, pFDR = .046, ηp2 = 0.053) and an age-related decrease in hippocampal–sgACC functional connectivity during SSL (F1,94 = 10.68, pFDR = .015, ηp2 = 0.102). We also show that hippocampal–sgACC functional connectivity mediated the association between interpersonal trauma exposure and post-traumatic stress disorder symptoms in an age-specific manner in the overall sample.Conclusion Together, these findings suggest that although age- and trauma-specific differences in the neural correlates of SSL may relate to the development of psychopathology, youth with interpersonal trauma exposure demonstrate successful learning of conditioned safety over time.Plain language summary Childhood trauma is a major risk factor for the development of psychiatric conditions such as posttraumatic stress disorder (PTSD). Using cross-sectional analysis, this study examined age-related differences in safety signal learning and its neural correlates among youth (N=102) ages 9 to 19 with and without exposure to interpersonal trauma. The authors found that youth exposed to trauma successfully learned about cues signaling safety; however, they showed age-related differences in hippocampal-frontoamygdala circuitry during safety signal learning that might relate to risk for PTSD at specific developmental stages. These findings can inform efforts to promote safety learning and optimize developmentally focused interventions for youth with PTSD.Diversity & Inclusion Statement We worked to ensure that the study questionnaires were prepared in an inclusive way. We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. While citing references scientifically relevant for this work, we also actively worked to promote sex and gender balance in our reference list. While citing references scientifically relevant for this work, we also actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our reference list. We actively worked to promote sex and gender balance in our author group. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. One or more of the authors of this paper received support from a program designed to increase minority representation in science.
Link: ./index.php?lvl=notice_display&id=31648
