Ziprasidone metabolism, aldehyde oxidase, and clinical implications / Christine Beedham en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 3 (Junio) . - pp. 229-232 Título : Ziprasidone metabolism, aldehyde oxidase, and clinical implications Tipo de documento: texto impreso Autores: Christine Beedham, Autor ; Jeffrey J. Miceli, Autor ; R. Scott Obach, Autor Fecha de publicación: 2023 Artículo en la página: pp. 229-232 Idioma : Inglés (eng) Idioma original : Inglés (eng) Etiquetas: Sistema enzimático citocromo P-450, Interacciones farmacológicas, Piperazinas, Tiazoles. Resumen: Ziprasidone (Geodon, Zeldox), a recently approved atypical antipsychotic agent for the treatment of schizophrenia, undergoes extensive metabolism in humans with very little (<5%) of the dose excreted as unchanged drug. Two enzyme systems have been implicated in ziprasidone metabolism: the cytosolic enzyme, aldehyde oxidase, catalyzes the predominant reductive pathway, and cytochrome P4503A4 (CYP3A4) is responsible for two alternative oxidation pathways. Link: ./index.php?lvl=notice_display&id=31018 [artículo] Ziprasidone metabolism, aldehyde oxidase, and clinical implications [texto impreso] / Christine Beedham, Autor ; Jeffrey J. Miceli, Autor ; R. Scott Obach, Autor . - 2023 . - pp. 229-232. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 3 (Junio) . - pp. 229-232 Etiquetas: Sistema enzimático citocromo P-450, Interacciones farmacológicas, Piperazinas, Tiazoles. Resumen: Ziprasidone (Geodon, Zeldox), a recently approved atypical antipsychotic agent for the treatment of schizophrenia, undergoes extensive metabolism in humans with very little (<5%) of the dose excreted as unchanged drug. Two enzyme systems have been implicated in ziprasidone metabolism: the cytosolic enzyme, aldehyde oxidase, catalyzes the predominant reductive pathway, and cytochrome P4503A4 (CYP3A4) is responsible for two alternative oxidation pathways. Link: ./index.php?lvl=notice_display&id=31018

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